Ampicillin - Resistant Non - β - Lactamase Producing 3 Haemophilus influenzae in Spain : Recent Emergence of 4 Clonal Isolates with Increased Resistance to Cefotaxime and
نویسندگان
چکیده
Cefixime. 6 7 8 9 10 11 12 Silvia García-Cobos 1 , José Campos 1,2* , Edurne Lázaro 3 , Federico 13 Román 1 , Emilia Cercenado 4 , César García-Rey 5 , María Pérez14 Vázquez 1 , Jesús Oteo 1 , Francisco de Abajo 3 15 16 17 18 1 Antibiotic Laboratory, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 19 Majadahonda, Madrid, Spain. 2 Consejo Superior de Investigaciones Científicas, Madrid, 20 Spain. 3 División de Farmacovigilancia, Agencia Española del Medicamento, Madrid, 21 Spain. 4 Microbiology Department, Hospital Gregorio Marañón, Madrid. 5 22 GlaxoSmithKline S.A., Madrid, Spain 23 24 25 26 27
منابع مشابه
Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime.
The sequence of the ftsI gene encoding the transpeptidase domain of penicillin-binding protein 3 (PBP 3) was determined for 354 nonconsecutive Haemophilus influenzae isolates from Spain; 17.8% of them were ampicillin susceptible, 56% were beta-lactamase nonproducing ampicillin resistant (BLNAR), 15.8% were beta-lactamase producers and ampicillin resistant, and 10.4% displayed both resistance me...
متن کاملIsolates of β-lactamase-negative ampicillin-resistant Haemophilus influenzae causing invasive infections in Spain remain susceptible to cefotaxime and imipenem.
OBJECTIVES The epidemiology of invasive Haemophilus influenzae has changed in recent years. β-Lactamase-negative ampicillin-resistant (BLNAR) invasive isolates have recently been described in Europe but their clinical significance is unclear. Our main goal was to determine whether invasive H. influenzae remains susceptible to β-lactam antibiotics indicated in the treatment of invasive infection...
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OBJECTIVES To determine the mechanisms of resistance to β-lactam antibiotics in clinical isolates of Haemophilus parainfluenzae. METHODS Twenty clinical isolates of H. parainfluenzae with decreased susceptibility to aminopenicillins were examined and compared with a control group of 20 fully susceptible isolates. In this collection, the presence of amino acid substitutions in the transpeptida...
متن کاملPrevalence, distribution and transfer of small β-lactamase-containing plasmids in Swedish Haemophilus influenzae.
OBJECTIVES The β-lactamase genes of Haemophilus influenzae are commonly positioned on large integrative and conjugative elements, but a group of blaTEM-carrying small plasmids (4000-6000 bp) with a common structural backbone have recently been characterized. In this study we investigated the epidemiological significance and potential for transfer of this group of small plasmids. METHODS We de...
متن کاملIn vitro activities of cefotaxime and moxalactam (LY127935) against Haemophilus influenzae.
The in vitro activities of two new beta-lactam antibiotics, cefotaxime and moxalactam (LY127935), were compared with those of cefamandole, cefoxitin, cefuroxime, and ampicillin against both beta-lactamase-producing and non-beta-lactamase-producing isolates of Haemophilus influenzae. Both cefotaxime and LY127935 were highly active against all isolates irrespective of beta-lactamase production.
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